Adolescents actively use music for affect regulation. In this chapter, affect is considered as a broad umbrella term containing moods, emotions, motivational impulses, and energy levels. Theoretical and empirical research has recently been unveiling the components involved in affect self-regulation, such as the psychological functions of music listening, affective goals, regulation strategies, and musical mechanisms. The study of these components and of their interactions has resulted in a better understanding of the dynamics between music engagement, wellbeing, and psychological development among adolescents. The purpose of this chapter is to present a conceptual model of musical affect self-regulation. The core components of the model are regulatory strategies and musical mechanisms, which interact across the dimensions of cognition, feelings, and bodily reactions.