This volume focuses on the role of interoception for mental life and lived experience, from the perspectives of neurosciences, psychological sciences, and philosophy. Interoception is the body-to-brain axis of signals originating from the internal body and visceral organs (such as gastrointestinal, respiratory, hormonal, and circulatory systems), and plays a unique role in ensuring homeostasis. This volume goes beyond the traditional role of interoception for homeostasis and offers a state-of-the-art overview of and new insights into the role of interoception for mental life, awareness, subjectivity, affect, and cognition. Structured across three parts, this multidisciplinary volume highlights the role that interoceptive signals and awareness thereof play in our mental life (Part I), considers deficits in interoceptive processing and awareness in various mental health conditions but also the equally important role of interoception for well-being (Part II), and approaches interoception from a theoretical and philosophical perspective, representing a highly novel departure for philosophy of mind and subjectivity (Part III). The chapters share a common concern for what it means to experience oneself, for the crucial role of emotions, and for issues of health and well-being, discussed on the joint basis of our bodily existence and interoception. The research presented here will hopefully accelerate the much-anticipated coming of age of interoceptive research in psychology, cognitive neurosciences, and philosophy.