This chapter describes occupational hazards for healthcare workers. The chapter focuses on biological hazards, chemical hazards, physical hazards, safety and ergonomic hazards, violence, psychosocial and organizational factors, and health consequences associated with changes in the organization and financing of healthcare. The nature and magnitude of various problems is described. The chapter includes specific prevention and control measures for addressing biological hazards, chemical hazards, ionizing radiation, safety hazards, ergonomic hazards, musculoskeletal disorders, violence, and psychosocial hazards. Finally, the chapter provides a summary of historical and recent policy initiatives, including federal and state laws, regulations and guidelines, developed and implemented to protect healthcare workers from recognized hazards.