RNase P: Beyond Precursor tRNA Processing-Reference-Cited by-同舟云学术

RNase P: Beyond Precursor tRNA Processing

Published:2024-02 Issue:1 Volume:22 Page:
ISSN:1672-0229
Container-title:Genomics, Proteomics & Bioinformatics
language:en
Short-container-title:

Author:

Wang Peipei¹^ORCID,Lin Juntao¹²^ORCID,Zheng Xiangyang³^ORCID,Xu Xingzhi¹^ORCID

Affiliation:

1. Guangdong Key Laboratory for Genome Stability & Disease Prevention and Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University , Shenzhen 518060, China

2. Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310000, China

3. Shenzhen University General Hospital-Dehua Hospital Joint Research Center on Precision Medicine, Dehua Hospital , Dehua 362500, China

Abstract

Abstract Ribonuclease P (RNase P) was first described in the 1970’s as an endoribonuclease acting in the maturation of precursor transfer RNAs (tRNAs). More recent studies, however, have uncovered non-canonical roles for RNase P and its components. Here, we review the recent progress of its involvement in chromatin assembly, DNA damage response, and maintenance of genome stability with implications in tumorigenesis. The possibility of RNase P as a therapeutic target in cancer is also discussed.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/gpb/advance-article-pdf/doi/10.1093/gpbjnl/qzae016/56666136/qzae016.pdf

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