A combination of polyglycolic acid fabric and fibrin glue prevents air leakage from a lung defect

Author:

Suzuki Akiyo1,Konishi Hayato1,Suzuki Tatsuya1,Katsumata Takahiro1,Hanaoka Nobuharu1,Nakamura Koichiro2,Matsubara Chisa2,Fujii Shota2,Nemoto Shintaro1ORCID

Affiliation:

1. Department of Thoracic and Cardiovascular Surgery, Osaka Medical and Pharmaceutical University , Takatsuki, Osaka, Japan

2. Division of Research and Development, Kyoto Medical Planning Co., Ltd ., Kyoto, Japan

Abstract

Abstract OBJECTIVES Air leakage after lung resection is a common morbidity that may lengthen hospital stay. Applying sealant to a lesion is an effective prophylaxis in clinical practice. This study aimed to examine the effect of a combination of a bioabsorbable polyglycolic acid (PGA) fabric and fibrin glue (FG) on air sealing by measuring the in vitro mechanical strength and degradation of the fabric, and in vivo histological changes after implantation. METHODS A defect was created in the canine left upper lung lobe, and then filled with a fibrinogen solution and covered with a PGA sheet spray-coated with fibrinogen and thrombin. After 1 and 4 weeks, air leakage from the lesion was examined in vivo under airway pressure. Tissue samples were harvested for histological assessment. RESULTS The mechanical strength of the PGA fabric remained at 80–90% of the baseline level for 1 week in phosphate-buffered saline, and then rapidly decreased to zero thereafter. Air leakage from the lung defect was prevented by the combination of PGA fabric and FG at 1 and 4 weeks. Histological examinations showed that PGA bundles persisted with a non-specific inflammatory response for 2 weeks and then gradually broke into sparse yarns surrounded by collagen fibres and capillaries by 8 weeks. The lung defect was filled with FG at 1 week and by granulation tissue thereafter. CONCLUSIONS These results provide evidence for the efficacy of a combination of PGA fabric and FG for the prevention of air leakage in the critical period after lung surgery.

Funder

Kyoto Medical Planning Co., Ltd., Kyoto, Japan

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine,Pulmonary and Respiratory Medicine,Surgery

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