Rapamycin reduced pulmonary vascular remodelling by inhibiting cell proliferation via Akt/mTOR signalling pathway down-regulation in the carotid artery–jugular vein shunt pulmonary hypertension rat model
Author:
Affiliation:
1. Department of Paediatric and Congenital Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Funder
National Natural Science Foundation of China
Publisher
Oxford University Press (OUP)
Subject
Cardiology and Cardiovascular Medicine,Pulmonary and Respiratory Medicine,Surgery
Link
http://academic.oup.com/icvts/article-pdf/25/2/206/19913660/ivx053.pdf
Reference21 articles.
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2. Pharmacological targets for pulmonary vascular disease: vasodilation versus anti-remodelling;Thomas;Adv Exp Med Biol,2010
3. Management of pulmonary arterial hypertension associated with congenital systemic-to-pulmonary shunts and Eisenmenger's syndrome;Galie;Drugs,2008
4. Pulmonary arterial hypertension in paediatric and adult patients with congenital heart disease;Gatzoulis;Eur Respir Rev,2009
5. Cellular and molecular basis of pulmonary arterial hypertension;Morrell;J Am Coll Cardiol,2009
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