1. Department of Molecular Cell Biology, Leiden University Medical Center, Eithovenweg 20, 2333 ZC Leiden, The Netherlands, 2 Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena, Italy and 3 Laboratory of Cell and Gene Therapy, Center for Chronic Immunodeficiency, University Medical Center Freiburg, Engesserstr. 4, 79108 Freiburg, Germany