1. Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109, USA, 2 Research Experiences for Undergraduates Program, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor MI 48109, USA and 3 Department of Microbiology, Ohio State University, 105 Biological Sciences Building, 484 West 12th Avenue, Columbus, OH 43210, USA