A Fatal Case Report of Barium Chloride Toxicity

Author:

Copeland Caroline S12ORCID,Rock Kirsten L1,Pinhal Andreia3,Chapman Robert C4,Chilcott Robert P3

Affiliation:

1. Institute of Pharmaceutical Sciences, King’s College London , Stamford Street, London SE1 9NQ, UK

2. National Programme on Substance Abuse Deaths, King's College London , Stamford Street, London SE1 9NQ, UK

3. Toxicology Research Group, University of Hertfordshire , Hatfield AL10 9AB, UK

4. Forensic Pathology Services , Aspect House, The Quadrangle, Grove Business Park, Wantage OX12 9FA, UK

Abstract

Abstract Barium is an alkaline earth metal whose toxicity is dictated by its compounded salt form: barium sulfate is insoluble and safe to ingest, but other barium salts (chloride, carbonate, sulfide, oxide and acetate) are bioavailable and therefore toxic when ingested. There have been 49 previous reports of fatal intoxications following barium consumption: 38 deemed accidental in nature, 8 suicidal, 1 homicidal and 2 of undetermined intent. In this report, we detail the first intentional fatal self-poisoning with barium chloride to be reported in the UK, along with a review of the surrounding literature. This is the first case to report quantified levels of barium in blood and vitreous humor, and by providing details of sample collection, storage and processing, this case will aid in future interpretations.

Publisher

Oxford University Press (OUP)

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology,Environmental Chemistry,Analytical Chemistry

Reference31 articles.

1. A study of barium sulphate preparations used as x-ray opaque media. I. Particle size and particle charge;James;Pharmaceutica Acta Helvetiae,1971

2. Misuse of drugs act;UK Government,1971

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