Loss of Consciousness and Visual Hallucinations Related to 5-MeO-DALT Intake, a Case Report Confirmed by Toxicological Analyses

Author:

Dufayet Laurène1234ORCID,Langrand Jérôme1,Alvarez Jean-Claude56,Islam Larabi Amine56

Affiliation:

1. Centre Antipoison de Paris—Fédération de Toxicologie (FeTox), Hôpital Fernand-Widal, APHP , 200 Rue du Faubourg Saint-Denis, Paris 75010, France

2. INSERM, UMRS-1144, Faculté de Pharmacie, Université Paris Cité, 4 Avenue de L’observatoire , Paris 75006, France

3. Unité Médico-judiciaire, Hôtel-Dieu, APHP , 1 Place du Parvis Notre Dame, Paris 75004, France

4. Faculté de Médecine, Université de Paris Cité, 15 Rue de L’école de Médecine , Paris 75006, France

5. Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré, APHP , 104 Bd Raymond Poincaré, Garches 92380, France

6. Plateforme de Spectrometrie de Masse (MasSpecLab) INSERM UMR 1173, UFR des Sciences de la Sante Simone Veil, Université Versailles Saint-Quentin-En-Yvelines (UVSQ-Paris Saclay) , Montigny le Bretonneux 78180, France

Abstract

Abstract 5-MeO-DALT or 5-methoxy-N,N-diallyltryptamine is a derivative of tryptamines, consumed for its hallucinogenic and entheogenic effects. We report the case of a 46-year-old-man, presenting with a brief loss of consciousness and visual hallucinations, after the consumption of three 5-MeO-DALT tablets bought online. Liquid chromatography coupled to tandem mass spectrometry method was performed, and 5-MeO-DALT was quantified in both the tablets (32.5 mg per tablet, 11% of purity) and the patient’s plasma (7 ng/mL—8 h between the consumption and the blood sample). 5-MeO-DALT poisonings are rarely described. Given the broad availability of these products, it is important that emergency department physicians and clinical toxicologists do not overlook the possibility of the ingestion of recreational tryptamines, especially since they are not detected by most routine toxicological screening.

Publisher

Oxford University Press (OUP)

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology,Environmental Chemistry,Analytical Chemistry

Reference17 articles.

1. Recreational use, analysis and toxicity of tryptamines;Tittarelli;Current Neuropharmacology,2015

2. The hallucinogenic world of tryptamines: an updated review;Araújo;Archives of Toxicology,2015

3. The Last Interview With Alexander Shulgin;Hamilton,2010

4. The recreational tryptamine 5-MeO-DALT (N,N-diallyl-5-methoxytryptamine): a brief review;Corkery;Progress in Neuro-psychopharmacology & Biological Psychiatry,2012

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