Leveraging Electronic Health Records to Construct a Phenotype for Hypertension Surveillance in the United States

Author:

He Siran1ORCID,Park Soyoun1,Kuklina Elena1,Therrien Nicole L1,Lundeen Elizabeth A2,Wall Hilary K1,Lampley Katrice13,Kompaniyets Lyudmyla4,Pierce Samantha L4,Sperling Laurence1,Jackson Sandra L1

Affiliation:

1. Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention , Atlanta, GA , USA

2. Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention , Atlanta, GA , USA

3. ASRT, INC , Smyrna, GA , USA

4. Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention , Atlanta, GA , USA

Abstract

Abstract BACKGROUND Hypertension is an important risk factor for cardiovascular diseases. Electronic health records (EHRs) may augment chronic disease surveillance. We aimed to develop an electronic phenotype (e-phenotype) for hypertension surveillance. METHODS We included 11,031,368 eligible adults from the 2019 IQVIA Ambulatory Electronic Medical Records-US (AEMR-US) dataset. We identified hypertension using three criteria, alone or in combination: diagnosis codes, blood pressure (BP) measurements, and antihypertensive medications. We compared AEMR-US estimates of hypertension prevalence and control against those from the National Health and Nutrition Examination Survey (NHANES) 2017–18, which defined hypertension as BP ≥130/80 mm Hg or ≥1 antihypertensive medication. RESULTS The study population had a mean (SD) age of 52.3 (6.7) years, and 56.7% were women. The selected three-criteria e-phenotype (≥1 diagnosis code, ≥2 BP measurements of ≥130/80 mm Hg, or ≥1 antihypertensive medication) yielded similar trends in hypertension prevalence as NHANES: 42.2% (AEMR-US) vs. 44.9% (NHANES) overall, 39.0% vs. 38.7% among women, and 46.5% vs. 50.9% among men. The pattern of age-related increase in hypertension prevalence was similar between AEMR-US and NHANES. The prevalence of hypertension control in AEMR-US was 31.5% using the three-criteria e-phenotype, which was higher than NHANES (14.5%). CONCLUSIONS Using an EHR dataset of 11 million adults, we constructed a hypertension e-phenotype using three criteria, which can be used for surveillance of hypertension prevalence and control.

Publisher

Oxford University Press (OUP)

Subject

Internal Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. State-Level Hypertension Prevalence and Control Among Adults in the U.S.;American Journal of Preventive Medicine;2024-01

2. Hypertension Prevalence and Control Among U.S. Women of Reproductive Age;American Journal of Preventive Medicine;2023-10

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