Characterizing interstitial lung disease in patients with psoriasis: a cross-sectional analysis in the National Institutes of Health’s All of Us Research Program

Abstract

We used a case–control design to investigate the electronic health record data of 156 707 participants from the National Institutes of Health’s All of Us Research Program to evaluate the association between psoriasis and interstitial lung disease (ILD). We demonstrated that the rate of ILD was significantly higher among those with psoriasis compared with among controls (4.5% vs. 2.2%; P < 0.001). Furthermore, using three multivariable models and controlling for several confounding variables, we demonstrated a consistent significant association between psoriasis and ILD, with the most stringent model demonstrating an odds ratio of 1.20 (95% confidence interval 1.04–1.39; P = 0.01).