An enlarging painless eyelid nodule

Abstract

A 50-year-old man with a history of kidney transplantation presented with a painless enlarging lesion on his right lower eyelid that had been growing for 2 years. A biopsy revealed a low-grade neoplasm with cribriform architecture and mucin production; subsequent immunohistochemistry was suggestive of endocrine mucin-producing sweat gland carcinoma. This case highlights the importance of a high index of suspicion for malignancy in immunocompromised patients with nonresolving lesions and the need for regular skin checks.