Left ventricular apical pacing-induced heart failure in a child after congenital heart surgery: a case report

Author:

De Wolf Rik1ORCID,van der Palen Roel L F1ORCID,ten Harkel Arend D J1ORCID,Hazekamp Mark G2ORCID,Blom Nico A13ORCID

Affiliation:

1. Department of Pediatrics, Division of Pediatric Cardiology, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden , The Netherlands

2. Department of Cardiothoracic Surgery, Leiden University Medical Center , Leiden , The Netherlands

3. Department of Pediatrics, Division of Pediatric Cardiology, Amsterdam UMC , Amsterdam , The Netherlands

Abstract

Abstract Background Left ventricular apical pacing (LVAP) is considered to preserve left ventricular (LV) systolic function in both patients with and without congenital heart disease. However, sporadic LVAP-associated cardiac dysfunction in children with complex structural heart disease was recently reported. We present the case of a 2.5-year-old child with complex congenital heart disease and LVAP-induced cardiomyopathy. Case summary Corrective surgery for double outlet right ventricle, subpulmonary ventricular septal defect, and transposition of the great arteries was done at the age of 1.5 months. Late complete atrioventricular block occurred, necessitating VVI pacemaker insertion with LV apical epicardial leads. He presented with heart failure and dilated cardiomyopathy 1.5 years after pacemaker insertion and required persistent circulatory support with intravenous inotropes. Speckle tracking echocardiography identified an important LV apical to basal dyssynchrony. After excluding any coronary artery involvement, cardiac resynchronization therapy was performed. Speckle tracking echocardiography guided lead placement resulted in improved LV contraction synchrony. Cardiac function recovered progressively in combination with oral heart failure medication and is almost normal at 10-month follow-up. Discussion Right ventricular pacing is a well-known cause of pacing-induced cardiomyopathy. The LV apex and LV free wall are thought to be most optimal locations for ventricular pacing in children. However, LVAP can also be the cause of a pacing-induced cardiomyopathy and decreased systolic LV function in children with complex congenital heart disease due to lack of LV contraction synchrony. Cardiac resynchronization therapy can reverse this LV dysfunction and remodelling.

Publisher

Oxford University Press (OUP)

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