Eight genes are necessary and sufficient for biogenesis of quinohemoprotein amine dehydrogenase-Reference-Cited by-同舟云学术

Eight genes are necessary and sufficient for biogenesis of quinohemoprotein amine dehydrogenase

Published:2021-06-30 Issue:9 Volume:85 Page:2026-2029
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Nakai Tadashi¹²³^ORCID,Tanizawa Katsuyuki³,Okajima Toshihide³

Affiliation:

1. Graduate School of Science and Technology, Hiroshima Institute of Technology, Hiroshima, Japan

2. Faculty of Life Sciences, Hiroshima Institute of Technology, Hiroshima, Japan

3. Institute of Scientific and Industrial Research (SANKEN), Osaka University, Osaka, Japan

Abstract

ABSTRACT Quinohemoprotein amine dehydrogenase (QHNDH) containing a peptidyl quinone cofactor, cysteine tryptophylquinone, is produced in the periplasm of Gram-negative bacteria through an intricate process of post-translational modification that requires at least 8 genes including those encoding 3 nonidentical subunits and 3 modifying enzymes. Our heterologous expression study has revealed that the 8 genes are necessary and sufficient for the QHNDH biogenesis.

Funder

JSPS

Cooperative Research Program of Network Joint Research Center for Materials and Devices

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbab117/39502848/zbab117.pdf

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