Analysis of the molecular evolution of histone variant H2A.Z using a linker-mediated complex strategy and yeast genetic complementation

Author:

Kitagawa Saho1,Kusakabe Masayuki1,Takahashi Daisuke1,Narimiya Takumi1,Nakabayashi Yu2,Seki Masayuki2,Horigome Chihiro1ORCID,Harata Masahiko1

Affiliation:

1. Graduate School of Agricultural Science, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

2. Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba-ku, Sendai, Miyagi, Japan

Abstract

ABSTRACT The histone variant H2A.Z is deposited into chromatin by specific machinery and is required for genome functions. Using a linker-mediated complex strategy combined with yeast genetic complementation, we demonstrate evolutionary conservation of H2A.Z together with its chromatin incorporation and functions. This approach is applicable to the evolutionary analyses of proteins that form complexes with interactors.

Funder

Japan Society for the Promotion of Science

Tohoku University

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Reference20 articles.

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