The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs-Reference-Cited by-同舟云学术

The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs

Published:2020-08-31 Issue:5 Volume:9 Page:609-621
ISSN:2045-4538
Container-title:Toxicology Research
language:en
Short-container-title:

Author:

Peng Junxuan¹,Cai Zuchao¹,Zhao Ruixue¹,Chen Jiahao¹,Liu Guochao¹,Dong Chao¹,Lim David²,Feng Zhihui¹

Affiliation:

1. Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Shandong, Jinan, 250012, China

2. School of Science and Health, Western Sydney University, Narellan Road, Campbelltown NSW 2560, Australia

Abstract

Abstract This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.

Funder

National Natural Science Foundation of China

Department of Science and Technology of Shandong Province

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://academic.oup.com/toxres/article-pdf/9/5/609/34053443/tfaa069.pdf

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