Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease-Reference-Cited by-同舟云学术

Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease

Published:2022-11-22 Issue: Volume: Page:
ISSN:1078-0998
Container-title:Inflammatory Bowel Diseases
language:en
Short-container-title:

Author:

Colman Ruben J¹,Samuels Abigail²,Mizuno Tomoyuki³⁴,Punt Nieko⁵,Vinks Alexander A³⁴,Minar Phillip¹³^ORCID

Affiliation:

1. Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center , Cincinnati, Ohio , USA

2. Department of Medicine, University of Cincinnati College of Medicine , Cincinnati, Ohio , USA

3. Department of Pediatrics, University of Cincinnati College of Medicine , Cincinnati, Ohio , USA

4. Division of Clinical Pharmacology, Cincinnati Children’s Hospital Medical Center , Cincinnati, Ohio , USA

5. Medimatics , Maastricht , The Netherlands

Abstract

Lay Summary It is increasingly recognized that inconsistent biologic therapeutic response is related to pharmacokinetic variability (drug clearance) between patients. This study highlights a multidisciplinary effort to integrate a precision dosing dashboard within the electronic health record to individualize biologic exposure starting and during induction.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Link

https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izac237/47194982/izac237.pdf

Reference10 articles.

1. Predictors of long-term clinical and endoscopic remission in children with Crohn disease treated with infliximab;D’Arcangelo;J Pediatr Gastroenterol Nutr.,2019

2. Real-world infliximab pharmacokinetic study informs an electronic health record-embedded dashboard to guide precision dosing in children with Crohn’s disease;Xiong;Clin Pharmacol Ther.,2021

3. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn’s disease: a prospective, multicentre, cohort study;Kennedy;Lancet Gastroenterol Hepatol.,2019