Balsalazide Exposure During the Development of Fertilizing Sperm May Be Associated With Offspring Birth Defects-Reference-Cited by-同舟云学术

Balsalazide Exposure During the Development of Fertilizing Sperm May Be Associated With Offspring Birth Defects

Published:2022-03-08 Issue:10 Volume:28 Page:1607-1609
ISSN:1078-0998
Container-title:Inflammatory Bowel Diseases
language:en
Short-container-title:

Author:

Wensink Maarten J¹²^ORCID,Streett Sarah E³,Damkier Per⁴⁵⁶^ORCID,Lindahl-Jacobsen Rune¹²,Kjeldsen Jens⁷^ORCID,Eisenberg Michael L⁸

Affiliation:

1. Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark ∗ , Odense , Denmark

2. Interdisciplinary Center on Population Dynamics, University of Southern Denmark , Odense , Denmark

3. Division of Gastroenterology and Hepatology, Stanford Medicine , Stanford, CA , USA

4. Department of Clinical Pharmacology, Odense University Hospital , Odense , Denmark

5. Department of Clinical Research, University of Southern Denmark , Odense , Denmark

6. Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark , Odense , Denmark

7. Department of Medical Gastroenterology S, Odense University Hospital and Research Unit of Medical Gastroenterology, Department of Clinical Research, University of Southern Denmark ∗∗ , Odense , Denmark

8. Male Reproductive Medicine and Surgery, Department of Urology and Department of Obstetrics and Gynecology, Stanford University , Stanford, CA , USA

Abstract

Lay Summary We report an association between balsalazide exposure during the development of fertilizing sperm and birth defects in offspring. Exposed offspring were approximately 8 times more likely to have a birth defect. There were no pre-existing reasons to suspect such a relationship, which should be confirmed in other data.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Link

https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izac038/42761278/izac038.pdf

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