(Re)Appraising Remission in Ulcerative Colitis

Author:

Sood Ajit1ORCID,Singh Arshdeep1ORCID,Mahajan Ramit1ORCID,Midha Vandana2,Bernstein Charles N3,Rubin David T4ORCID

Affiliation:

1. Department of Gastroenterology, Dayanand Medical College and Hospital , Ludhiana, Punjab , India

2. Department of Internal Medicine, Dayanand Medical College and Hospital , Ludhiana, Punjab , India

3. IBD Clinical and Research Centre and Section of Gastroenterology, Department of Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg, Manitoba , Canada

4. Inflammatory Bowel Disease Center, University of Chicago Medicine , Chicago, IL , USA

Abstract

Abstract As the therapeutic targets in ulcerative colitis (UC) shift from control of symptoms to mucosal healing and prevention of disease complications like disability, colectomy, and cancer, the definition of remission has evolved. The current definition of clinical remission is variable and is determined by the clinical context in which it is being used. This results in skepticism and uncertainty about the true meaning of the term “clinical remission.” In this review, the authors reexamine the definition of clinical remission and propose a novel approach to define remission in UC.

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

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