The Modified Mucosal Inflammation Noninvasive Index and Endoscopic Remission in Adults With Crohn’s Disease

Author:

Yogev Dotan12ORCID,Verstockt Bram34ORCID,Dignass Axel5,Focht Gili12,Atia Ohad2,Dotan Iris67,Vermeire Severine34ORCID,Turner Dan12

Affiliation:

1. Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center , Jerusalem , Israel

2. Hebrew University of Jerusalem , Jerusalem , Israel

3. Department of Gastroenterology and Hepatology, University Hospital Leuven, KU Leuven , Leuven , Belgium

4. Department of Chronic Diseases and Metabolism, KU Leuven , Leuven , Belgium

5. Department of Medicine I, Agaplesion Markus Hospital , Frankfurt , Germany

6. Division of Gastroenterology, Rabin Medical Center , Petah Tikva , Israel and

7. Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel

Abstract

Lay Summary The Mucosal Inflammation Noninvasive Index is a validated noninvasive tool to assess endoscopic remission in pediatric Crohn’s disease. In this study, we evaluated a modified version of the Mucosal Inflammation Noninvasive Index on adult cohorts to explore its validly in adult Crohn’s disease.

Funder

Clinical Research Fund

University Hospitals Leuven

Research Council of KU Leuven

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Reference12 articles.

1. STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD;Turner;Gastroenterology.,2021

2. Current noninvasive modalities in Crohn’s disease monitoring;Mitselos;Ann Gastroenterol.,2021

3. Association of biomarker cutoffs and endoscopic outcomes in Crohn’s disease: a post hoc analysis from the CALM study;Reinisch;Inflamm Bowel Dis.,2020

4. Predicting endoscopic disease activity in Crohn’s disease: a new and validated noninvasive disease activity index (The Utrecht Activity Index);Minderhoud;Inflamm Bowel Dis.,2015

5. Development and validation of the mucosal inflammation noninvasive index for pediatric Crohn’s disease;Cozijnsen;Clin Gastroenterol Hepatol.,2020

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