A Systematic Literature Review of Peripheral Nerve Stimulation Therapies for the Treatment of Pain

Author:

Deer Timothy R1,Esposito Michael F2,McRoberts W Porter3,Grider Jay S4,Sayed Dawood5,Verrills Paul6,Lamer Tim J7,Hunter Corey W8,Slavin Konstantin V9,Shah Jay M10,Hagedorn Jonathan M11,Simopoulos Tom12,Gonzalez David Abejon13,Amirdelfan Kasra14,Jain Sameer15,Yang Ajax16,Aiyer Rohit17,Antony Ajay18,Azeem Nomen19,Levy Robert M20,Mekhail Nagy21

Affiliation:

1. The Spine and Nerve Center of the Virginias, Charleston, West Virginia

2. Florida Pain Institute, Melbourne, Florida

3. Anodyne Research, PA, University of Miami, Miami, Florida

4. UKHealthCare Pain Services, Department of Anesthesiology, University of Kentucky College of Medicine, Lexington, Kentucky

5. University of Kansas Medical Center, Kansas City, Kansas, USA

6. Metro Spinal Clinic, Melbourne, Victoria, Australia

7. Division of Pain Medicine, Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota

8. Ainsworth Institute of Pain Management, New York, New York

9. Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois

10. SamWell Institute for Pain Management, Colonia, New Jersey

11. Mayo Clinic, Rochester, Minnesota

12. Department of Anesthesiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

13. Pain Unit, Hospital Universitario Quirón-Salud, Madrid, Spain

14. IPM Medical Group, Walnut Creek, California

15. Pain Treatment Centers of America, Little Rock, Arkansas

16. Mt. Sinai Hospital, New York, New York

17. Interventional Pain Management and Pain Psychiatry Faculty, Henry Ford Health System, Detroit, Michigan

18. University of Florida College of Medicine, Jacksonville, Florida

19. Florida Spine & Pain Specialists, Bradenton, Florida

20. Director of Neurosurgical Services, Director of Clinical Research, Anesthesia Pain Care Consultants, Tamarac, Florida

21. Evidence-Based Pain Management Research and Education, Cleveland Clinic, Cleveland, Ohio, USA

Abstract

AbstractObjectiveTo conduct a systematic literature review of peripheral nerve stimulation (PNS) for pain.DesignGrade the evidence for PNS.MethodsAn international interdisciplinary work group conducted a literature search for PNS. Abstracts were reviewed to select studies for grading. Inclusion/exclusion criteria included prospective randomized controlled trials (RCTs) with meaningful clinical outcomes that were not part of a larger or previously reported group. Excluded studies were retrospective, had less than two months of follow-up, or existed only as abstracts. Full studies were graded by two independent reviewers using the modified Interventional Pain Management Techniques–Quality Appraisal of Reliability and Risk of Bias Assessment, the Cochrane Collaborations Risk of Bias assessment, and the US Preventative Services Task Force level-of-evidence criteria.ResultsPeripheral nerve stimulation was studied in 14 RCTs for a variety of painful conditions (headache, shoulder, pelvic, back, extremity, and trunk pain). Moderate to strong evidence supported the use of PNS to treat pain.ConclusionPeripheral nerve stimulation has moderate/strong evidence. Additional prospective trials could further refine appropriate populations and pain diagnoses.

Publisher

Oxford University Press (OUP)

Subject

Anesthesiology and Pain Medicine,Neurology (clinical),General Medicine

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