A Systematic Literature Review of Dorsal Root Ganglion Neurostimulation for the Treatment of Pain

Author:

Deer Timothy R1,Hunter Corey W2,Mehta Pankaj3,Sayed Dawood4,Grider Jay S5,Lamer Tim J6,Pope Jason E7,Falowski Steven8,Provenzano David A9,Esposito Michael F10,Slavin Konstantin V11,Baranidharan Ganesan12,Russo Marc13,Jassal Navdeep S14,Mogilner Alon Y15,Kapural Leo16,Verrills Paul17,Amirdelfan Kasra18,McRoberts W Porter19,Harned Michael E20,Chapman Kenneth B21,Liem Liong22,Carlson Jonathan D23,Yang Ajax24,Aiyer Rohit25,Antony Ajay26,Fishman Michael A27,Al-Kaisy Adnan A28,Christelis Nick29,Levy Robert M30,Mekhail Nagy31

Affiliation:

1. Spine and Nerve Center of the Virginias, Charleston, West Virginia

2. Ainsworth Institute of Pain Management, New York, New York

3. Pain Specialists of America, Austin, Texas

4. University of Kansas Medical Center, Kansas City, Kansas

5. UK HealthCare Pain Services, Department of Anesthesiology, University of Kentucky College of Medicine, Lexington, Kentucky

6. Division of Pain Medicine, Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota

7. Evolve Restorative Center, Santa Rosa, California

8. Department of Neurosurgery, Neurosurgical Associates of Lancaster, Lancaster, Pennsylvania

9. Pain Diagnostics and Interventional Care, Sewickley, Pennsylvania

10. Florida Pain Institute, Melbourne, Florida

11. Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, USA

12. Leeds Teaching Hospital, NHS Trust, Leeds, UK

13. Hunter Pain Specialists, Broadmeadow, NSW, Australia

14. Department of Neurology/Pain, University of South Florida, Spine & Pain Institute of Florida, Lakeland, Florida

15. Department of Neurosurgery, NYU Langone Medical Center, New York, New York

16. Carolina Pain Institute at Brookstown, Wake Forest Baptist Health, Winston-Salem, North Carolina, USA

17. Metro Spinal Clinic, Melbourne, Victoria, Australia

18. IPM Medical Group, Walnut Creek, California

19. Anodyne Research, Pennsylvania

20. Department of Anesthesiology, University of Kentucky, Lexington, Kentucky

21. The Spine Institute of New York, New York, New York, USA

22. St. Antonius Hospital, Nieuwegein, the Netherlands

23. Arizona Pain/Pain Doctor, Midwestern Medical School, Glendale, Arizona

24. Mt. Sinai Hospital, New York, New York

25. Interventional Pain Management and Pain Psychiatry Faculty, Henry Ford Health System Detroit, Michigan

26. University of Florida College of Medicine, Jacksonville, Florida

27. Center for Interventional Pain and Spine, Bryn Mawr, Pennsylvania, USA

28. Pain Management and Neuromodulation Centre at Guy’s and St. Thomas’ NHS Trust, London, UK

29. Pain Specialists Australia, Monash University, Richmond, Victoria, Australia

30. Neurosurgical Services and of Clinical Research, Anesthesia Pain Care Consultants, Tamarac, Florida

31. Evidence-Based Pain Management Research and Education, Cleveland Clinic, Cleveland, Ohio, USA

Abstract

AbstractObjectiveTo conduct a systematic literature review of dorsal root ganglion (DRG) stimulation for pain.DesignGrade the evidence for DRG stimulation.MethodsAn international, interdisciplinary work group conducted a literature search for DRG stimulation. Abstracts were reviewed to select studies for grading. General inclusion criteria were prospective trials (randomized controlled trials and observational studies) that were not part of a larger or previously reported group. Excluded studies were retrospective, too small, or existed only as abstracts. Studies were graded using the modified Interventional Pain Management Techniques–Quality Appraisal of Reliability and Risk of Bias Assessment, the Cochrane Collaborations Risk of Bias assessment, and the US Preventative Services Task Force level-of-evidence criteria.ResultsDRG stimulation has Level II evidence (moderate) based upon one high-quality pivotal randomized controlled trial and two lower-quality studies.ConclusionsModerate-level evidence supports DRG stimulation for treating chronic focal neuropathic pain and complex regional pain syndrome.

Publisher

Oxford University Press (OUP)

Subject

Anesthesiology and Pain Medicine,Clinical Neurology,General Medicine

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