Processing of Laser-Evoked Potentials in Patients with Chronic Whiplash-Associated Disorders, Chronic Fatigue Syndrome, and Healthy Controls: A Case–Control Study

Author:

Goudman Lisa123,Daenen Liesbeth234,Mouraux Andre5,Nijs Jo236,Cras Patrick789,Roussel Nathalie10,Moens Maarten11112,Coppieters Iris236,Huysmans Eva23613,De Kooning Margot236

Affiliation:

1. Department of Neurosurgery, Universitair Ziekenhuis Brussel, Brussels, Belgium

2. Pain in Motion International Research Group

3. Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium

4. Knowledge, Information and Research Center (KIR), Group Idewe, Louvain, Belgium

5. Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium

6. Department of Physical Medicine and Physiotherapy, Universitair Ziekenhuis Brussel, Brussels, Belgium

7. Laboratory of Neurology, Translational Neurosciences, University of Antwerp, Wilrijk, Belgium

8. Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium

9. Department of Neurology, Antwerp University Hospital, Edegem, Belgium

10. Department of Rehabilitation Sciences and Physiotherapy (MOVANT), Faculty of Medicine and Health Sciences, University of Antwerp, Campus, Drie Eiken, Wilrijk, Belgium

11. Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium

12. Department of Radiology, Universitair Ziekenhuis Brussel, Brussels, Belgium

13. Department of Public Health (GEWE), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium

Abstract

Abstract Objective Laser-evoked potentials (LEPs) are among the reliable neurophysiological tools to investigate patients with neuropathic pain, as they can provide an objective account of the functional status of thermo-nociceptive pathways. The goal of this study was to explore the functioning of the nociceptive afferent pathways by examining LEPs in patients with chronic whiplash-associated disorders (cWAD), patients with chronic fatigue syndrome (CFS), and healthy controls (HCs). Design Case–control study. Setting A single medical center in Belgium. Subjects The LEPs of 21 patients with cWAD, 19 patients with CFS, and 18 HCs were analyzed in this study. Methods All participants received brief nociceptive CO2 laser stimuli applied to the dorsum of the left hand and left foot while brain activity was recorded with a 32-channel electroencephalogram (EEG). LEP signals and transient power modulations were compared between patient groups and HCs. Results No between-group differences were found for stimulus intensity, which was supraliminal for Aδ fibers. The amplitudes and latencies of LEP wave components N1, N2, and P2 in patients with cWAD and CFS were statistically similar to those of HCs. There were no significant differences between the time–frequency maps of EEG oscillation amplitude between HCs and both patient populations. Conclusions EEG responses of heat-sensitive Aδ fibers in patients with cWAD and CFS revealed no significant differences from the responses of HCs. These findings thus do not support a state of generalized central nervous system hyperexcitability in those patients.

Funder

ME Research UK

Publisher

Oxford University Press (OUP)

Subject

Anesthesiology and Pain Medicine,Clinical Neurology,General Medicine

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