Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium†

Author:

Figueroa Jonine D.1,Garcia-Closas Montserrat2,Humphreys Manjeet3,Platte Radka3,Hopper John L.4,Southey Melissa C.5,Apicella Carmel4,Hammet Fleur5,Schmidt Marjanka K.6,Broeks Annegien6,Tollenaar Rob A.E.M.7,Van't Veer Laura J.6,Fasching Peter A.8,Beckmann Matthias W.9,Ekici Arif B.10,Strick Reiner9,Peto Julian11,dos Santos Silva Isabel11,Fletcher Olivia12,Johnson Nichola12,Sawyer Elinor1314,Tomlinson Ian15,Kerin Michael16,Burwinkel Barbara1718,Marme Federik1719,Schneeweiss Andreas1719,Sohn Christof17,Bojesen Stig20,Flyger Henrik21,Nordestgaard Børge G.20,Benítez Javier22,Milne Roger L.23,Ignacio Arias Jose24,Zamora M. Pilar25,Brenner Hermann26,Müller Heiko26,Arndt Volker26,Rahman Nazneen27,Turnbull Clare27,Seal Sheila27,Renwick Anthony27,Brauch Hiltrud28,Justenhoven Christina28,Brüning Thomas29,Chang-Claude Jenny30,Hein Rebecca30,Wang-Gohrke Shan31,Dörk Thilo32,Schürmann Peter32,Bremer Michael33,Hillemanns Peter34,Nevanlinna Heli35,Heikkinen Tuomas35,Aittomäki Kristiina36,Blomqvist Carl37,Bogdanova Natalia38,Antonenkova Natalia39,Rogov Yuri I.40,Karstens Johann Hinrich41,Bermisheva Marina42,Prokofieva Darya42,Hanafievich Gantcev Shamil43,Khusnutdinova Elza44,Lindblom Annika45,Margolin Sara45,Chenevix-Trench Georgia46,Beesley Jonathan46,Chen Xiaoqing46,Mannermaa Arto4748,Kosma Veli-Matti4748,Soini Ylermi4748,Kataja Vesa4950,Lambrechts Diether51,Yesilyurt Betül T.51,Chrisiaens Marie-Rose52,Peeters Stephanie52,Radice Paolo53,Peterlongo Paolo5354,Manoukian Siranoush55,Barile Monica56,Couch Fergus57,Lee Adam M.58,Diasio Robert58,Wang Xianshu57,Giles Graham G.59,Severi Gianluca59,Baglietto Laura59,Maclean Catriona60,Offit Ken61,Robson Mark61,Joseph Vijai61,Gaudet Mia62,John Esther M.6364,Winqvist Robert65,Pylkäs Katri65,Jukkola-Vuorinen Arja66,Grip Mervi67,Andrulis Irene68,Knight Julia A.69,Marie Mulligan Anna70,O'Malley Frances P.7172,Brinton Louise A.1,Sherman Mark E.1,Lissowska Jolanta73,Chanock Stephen J.1,Hooning Maartje74,Martens John W.M.75,van den Ouweland Ans M.W.76,Collée J. Margriet76,Hall Per77,Czene Kamila77,Cox Angela78,Brock Ian W.78,Reed Malcolm W.R.78,Cross Simon S.79,Pharoah Paul3,Dunning Alison M.3,Kang Daehee80,Yoo Keun-Young80,Noh Dong-Young80,Ahn Sei-Hyun81,Jakubowska Anna82,Lubinski Jan82,Jaworska Katarzyna82,Durda Katarzyna82,Sangrajrang Suleeporn83,Gaborieau Valerie84,Brennan Paul84,McKay James84,Shen Chen-Yang85,Ding Shian-ling86,Hsu Huan-Ming87,Yu Jyh-Cherng87,Anton-Culver Hoda88,Ziogas Argyrios88,Ashworth Alan12,Swerdlow Anthony12,Jones Michael12,Orr Nick12,Trentham-Dietz Amy89,Egan Kathleen90,Newcomb Polly8991,Titus-Ernstoff Linda9293,Easton Doug3,Spurdle Amanda B.94, ,

Affiliation:

1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA,

2. Sections of Epidemiology and Genetics and

3. United Kingdom Department of Oncology and Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

4. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Genetic and Analytic Epidemiology and

5. Department of Pathology, The University of Melbourne, Melbourne, Vic, Australia

6. Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands,

7. Leiden University Medical Center, Leiden, The Netherlands,

8. Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA,

9. Department of Gynecology and Obstetrics, University Hospital Erlangen and

10. Institute of Human Genetics, Friedrich-Alexander University, Erlangen, Germany,

11. Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel St., London, UK,

12. Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK,

13. National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre, Guy's and St. Thomas’ NHS Foundation Trust in partnership with King's College London, London, UK,

14. NHS Foundation Trust, King's College Hospital, London, UK,

15. Welcome Trust Centre for Human Genetics and Oxford Comprehensive Biomedical Research Centre, University of Oxford, UK,

16. Clinical Science Institute. University Hospital Galway, Galway, Ireland,

17. Department of Obstetrics and Gynecology and

18. Molecular Epidemiology Group,

19. National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany,

20. Department of Clinical Biochemistry, Copenhagen University Hospital and

21. Department of Breast Surgery, Copenhagen University Hospital, Herlev Hospital, Denmark,

22. Cancer Research Group, Human Genetics Programme and

23. Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain,

24. Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain,

25. Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain,

26. Division of Clinical Epidemiology and Aging Research and

27. Section of Cancer Genetics, The Institute of Cancer Research, Sutton, UK,

28. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Germany,

29. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany,

30. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany,

31. Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany,

32. Gynecology Research Unit,

33. Clinics of Radiation Oncology,

34. Clinics of Obstetrics and Gynecology,

35. Department of Obstetrics and Gynecology

36. Department of Clinical Genetics and

37. Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland,

38. Gynecology Research Unit and Clinics of Radiation Oncology and

39. Belarusian Institute for Oncology and Medical Radiology, Minsk, Belarus,

40. Department of Pathology, Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus,

41. Clinics of Radiation Oncology, Hannover Medical School, Hannover, Germany,

42. Institute of Biochemistry and Genetics and

43. Department of Surgery and Oncology, Bashkir State Medical University, Ufa, Russia,

44. Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Science, Ufa, Russia,

45. Karolinska Institute, Stockholm, Sweden,

46. Queensland Institute of Medical Research, Herston, Australia,

47. Institute of Clinical Medicine, Pathology and Forensic Medicine and

48. Department of Pathology, Cancer Center of Eastern Finland and

49. Institute of Clinical Medicine, Oncology, University of Eastern Finland, Biocenter Kuopio, Kuopio, Finland,

50. Department of Oncology, Cancer Center of Eastern Finland, Kuopio University Hospital, Kuopio, Finland,

51. Vesalius Research Center, VIB and University of Leuven, Leuven, Belgium,

52. Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium,

53. Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, and

54. IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy,

55. Department of Preventive and Predictive Medicine, Unit of Medical Genetics, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy,

56. Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy,

57. Department of Laboratory Medicine and Pathology and

58. Department of Pharmacology, Mayo Clinic, Rochester, MN, USA,

59. Cancer Epidemiology Centre, Cancer Council, Victoria, Australia,

60. Department of Anatomical Pathology, Alfred Hospital, Victoria, Australia,

61. Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, Cornell Weill Medical College, New York, NY, USA,

62. American Cancer Society, Genetic  Epidemiology Unit, Atlanta, GA, USA,

63. Cancer Prevention Institute of California, Fremont, CA, USA,

64. Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA,

65. Department of Clinical Genetics, Laboratory of Cancer Genetics and Biocenter Oulu, Oulu University Hospital,

66. Department of Oncology, Oulu University Hospital and

67. Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland,

68. Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada,

69. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Prosserman Centre for Health Research, Toronto, Canada,

70. Department of Laboratory Medicine, St. Michael's Hospital and the University of Toronto, Toronto, Canada,

71. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada,

72. Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada,

73. Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland,

74. Department of Medical Oncology, Family Cancer Clinic,

75. Department of Medical Oncology, Josephine Nefkens Institute and

76. Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands,

77. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm,

78. Dept of Oncology, Faculty of Medicine, Dentistry and Health and

79. Department of Neuroscience, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK,

80. Seoul National University College of Medicine, Soul, Korea,

81. University of Ulsan College of Medicine, Asan Medical Center, Soul, Korea,

82. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland,

83. National Cancer Institute, Bangkok, Thailand,

84. International Agency for Research on Cancer, Lyon, France,

85. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan,

86. Department of Nursing, Kang-Ning Junior College of Medical Care and Management, Taipei, Taiwan,

87. Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan,

88. Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, CA, USA,

89. University of Wisconsin Carbone Cancer Center, Madison, WI, USA,

90. Division of Population Sciences, Moffitt Cancer Center and Research Institute, Tampa, FL, USA,

91. Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington DC, USA and

92. Department of Community and Family Medicine and

93. Department of Pediatrics , Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, USA

94. Genetics and Population Health Division, Queensland Institute of Medical Research, Herston, Brisbane, Australia,

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

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