1. Division of Gastroenterology, Department of Medicine, University of Alberta , Edmonton, AB , Canada
2. NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham , Nottingham , UK
3. Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham , Nottingham , UK
4. MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham , Birmingham , UK
5. School of Life Sciences, University of Nottingham , Nottingham , UK