Pharmacokinetics and Immune Reconstitution Following Discontinuation of Thiopurine Analogues: Implications for Drug Withdrawal Strategies-Reference-Cited by-同舟云学术

Pharmacokinetics and Immune Reconstitution Following Discontinuation of Thiopurine Analogues: Implications for Drug Withdrawal Strategies

Published:2018-08-27 Issue:12 Volume:12 Page:1410-1417
ISSN:1873-9946
Container-title:Journal of Crohn's and Colitis
language:en
Short-container-title:

Author:

Ben-Horin Shomron¹²,Van Assche Gert³,Chowers Yehuda⁴,Fudim Ella¹,Ungar Bella¹,Picard Orit¹,Yavzori Miri¹,Kopylov Uri¹,Mao Ren²,Chen Min-hu²,Peled Yael⁵,Gueta Itai⁶,Eliakim Rami¹,Loebstein Ronen¹,Markovits Noa⁷

Affiliation:

1. Department of Gastroenterology, Sheba Medical Center Tel Hashomer & Sackler School of Medicine, Tel-Aviv University, Israel

2. Department of Gastroenterology, First Affiliated Hospital, Sun YatSen University, Guangzhou, China

3. Division of Gastroenterology and Hepatology, University Hospitals Leuven, Belgium

4. Rambam Health Care Campus & Bruce Rappaport School of Medicine, Technion Institute of Technology, Haifa, Israel

5. The Olga and Lev Leviev Heart Center, Sheba Medical Center Tel Hashomer & Sackler School of Medicine, Tel-Aviv University, Israel

6. Institute of Clinical Pharmacology, Sheba Medical Center Tel Hashomer, Tel-Aviv University, Israel

7. The Institute of Clinical Pharmacology, Sheba Medical Center Tel Hashomer & Sackler School of Medicine, Tel-Aviv University, Israel

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,General Medicine

Link

http://academic.oup.com/ecco-jcc/article-pdf/12/12/1410/26770394/jjy122.pdf

Reference29 articles.

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3. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease;Dubinsky;Gastroenterology,2000

4. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes;Tiede;J Clin Invest,2003

5. Thiopurine prodrugs mediate immunosuppressive effects by interfering with Rac1 protein function;Shin;J Biol Chem,2016

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