Molecular Profiling of Ulcerative Colitis Subjects from the TURANDOT Trial Reveals Novel Pharmacodynamic/Efficacy Biomarkers

Author:

Zhou Huanyu1,Xi Li1,Ziemek Daniel1,O’Neil Shawn1,Lee Julie1,Stewart Zachary1,Zhan Yutian1,Zhao Shanrong1,Zhang Ying1,Page Karen1,Huang Austin1,Maciejewski Mateusz1,Zhang Baohong1ORCID,Gorelick Kenneth J1,Fitz Lori1,Pradhan Vivek1,Cataldi Fabio1,Vincent Michael1,Von Schack David1,Hung Kenneth1,Hassan-Zahraee Mina1

Affiliation:

1. Pfizer, Cambridge, MA, USA

Funder

Pfizer

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,General Medicine

Reference24 articles.

1. Inflammatory bowel disease;Podolsky;N Engl J Med,2002

2. Novel therapies and treatment strategies for patients with inflammatory bowel disease;Duijvestein;Curr Treat Options Gastroenterol,2018

3. Pharmacological characterization of PF-00547659, an anti-human MAdCAM monoclonal antibody;Pullen;Br J Pharmacol,2009

4. Anti-MAdCAM antibody [PF-00547659] for ulcerative colitis [TURANDOT]: a phase 2, randomised, double-blind, placebo-controlled trial;Vermeire;Lancet,2017

5. Central reading of endoscopy endpoints in inflammatory bowel disease trials;Gottlieb;Inflamm Bowel Dis,2015

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