The Importance of Molecular Immune Investigation in Therapeutic Clinical Development for Biomarker Assessment

Author:

Lamb Christopher A12,Mansfield John C12,Kirby John A1,Keir Mary E3

Affiliation:

1. Newcastle University, Newcastle upon Tyne, UK

2. Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

3. Genentech Inc., South San Francisco, CA, USA

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,General Medicine

Reference14 articles.

1. Gut-selective integrin-targeted therapies for inflammatory bowel disease;Lamb;J Crohns Colitis,2018

2. Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial;Vermeire;Lancet,2014

3. AlphaE integrin expression is increased in the ileum relative to the colon and unaffected by inflammation;Ichikawa;J Crohns Colitis,2018

4. AlphaE expression in IBD: a biomarker for the use of etrolizumab;Roosenboom;J Crohns Colitis,2018

5. A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes;Cerf-Bensussan;Eur J Immunol,1987

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