Results of the Eighth Scientific Workshop of ECCO: Pathophysiology and Risk Factors of Postoperative Crohn’s Disease Recurrence after an Ileocolonic Resection

Author:

Rivière Pauline1ORCID,Bislenghi Gabriele2ORCID,Hammoudi Nassim3,Verstockt Bram45ORCID,Brown Steven6ORCID,Oliveira-Cunha Melissa7,Bemelman Willem8,Pellino Gianluca9ORCID,Kotze Paulo Gustavo10ORCID,Dragoni Gabriele,Allocca Mariangela,Noor Nurulamin M,Pouillon Lieven,Mañosa Míriam,Savarino Edoardo,Allez Matthieu,Kapizioni Christina,Arebi Naila,Carvello Michele,De Vries Annemarie C,Domènech Eugeni,Myrelid Pär,Ferrante Marc45ORCID,Panis Yves11ORCID,

Affiliation:

1. Department of Gastroenterology and Hepatology, Centre Médico-chirurgical Magellan, Hôpital Haut-Lévêque, CHU de Bordeaux, Université de Bordeaux, INSERM CIC 1401, Bordeaux , France

2. Department of Abdominal Surgery, University Hospitals Leuven, KU Leuven , Leuven , Belgium

3. Department of Gastroenteology, Hôpital Saint-Louis, APHP, INSERM U1160, Université Paris Cité , Paris , France

4. Department of Gastroenterology and Hepatology, University Hospitals Leuven , Leuven , Belgium

5. Translational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven , Leuven , Belgium

6. Department of Surgery, Sheffield Teaching Hospitals , Sheffield , UK

7. Department of Colorectal Surgery, University Hospitals of Birmingham NHS Trust , Birmingham , UK

8. Department of Surgery, Amsterdam University Medical Centers , location Meibergdreef, Amsterdam , the Netherlands

9. Department of Advanced Medical and Surgical Science, Università Degli Studi Della Campania Luigi Vanvitelli , Naples , Italy

10. IBD Outpatient Clinics, Colorectal Surgery Unit, Pontifícia Universidade Católica do Paraná (PUCPR) , Curitiba , Brazil

11. Paris IBD Center, Groupe Hospitalier Privé Ambroise Paré-Hartmann , Neuilly/Seine , France

Abstract

Abstract Postoperative recurrence [POR] after an ileocolonic resection with ileocolonic anastomosis is frequently encountered in patients with Crohn’s disease. The 8th Scientific Workshop of ECCO reviewed the available evidence on the pathophysiology and risk factors for POR. In this paper, we discuss published data on the role of the microbiome, the mesentery, the immune system and the genetic background. In addition to investigating the causative mechanisms of POR, identification of risk factors is essential to tailor preventive strategies. Potential clinical, surgical and histological risk factors are presented along with their limitations. Emphasis is placed on unanswered research questions, guiding prevention of POR based on individual patient profiles.

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,General Medicine

Reference110 articles.

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