A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma-Reference-Cited by-同舟云学术

A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma

Published:2003-04-01 Issue:2 Volume:5 Page:96-103
ISSN:1523-5866
Container-title:Neuro-Oncology
language:en
Short-container-title:

Author:

Prados Michael D.,Schold S. Clifford,Fine Howard A.,Jaeckle Kurt,Hochberg Fred,Mechtler Laszlo,Fetell Michael R.,Phuphanich Surasak,Feun Lynn,Janus Todd J.,Ford Kathleen,Graney William

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Clinical Neurology,Oncology

Link

http://academic.oup.com/neuro-oncology/article-pdf/5/2/96/13065914/03-NO5.2-Prados.pdf

Reference15 articles.

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2. Bartus, R.T., Elliott, P.J., Dean, R.L., Hayward, N.J., Nagle, R.L., Huff, M.R., Snodgrass, P.A., and Blunt, D.G. (1996b) Controlled modulation of the BBB permeability using the bradykinin agonist, RMP-7. Exp. Neurol.142,14 -28.

3. Bartus, R.T., Snodgrass, P., Marsh, J., Agostino, M., Perkins, A., and Emerich, D.F. (2000) Intravenous Cereport (RMP-7) modifies topographic uptake profile of carboplatin within rat glioma and brain surrounding tumor, elevates platinum levels, and enhances survival. J. Pharmacol. Exp. Ther.293,903 -911.

4. Cloughesy, T., Black, K.L., Gobin, Y., Farahani, K., Nelson, G., Villablanca, P., Kabbinavar, F., Vinuela, F., and Wortel, C. (1999) Intra-arterial Cereport (RMP-7) and carboplatin: A dose escalation study for recurrent malig nant gliomas. Neurosurgery44,270 -278.

5. Elliott, P.J., Hayward, N.J., Deen, R.L., Blunt, D.G., and Bartus, R.T. (1996) Intravenous RMP-7 selectively increases uptake of carboplatin into rat brain tumors. Cancer Res.56,3998 -4005.

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