Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models

Author:

Landersdorfer Cornelia B123,Wang Jiping1,Wirth Veronika1,Chen Ke1,Kaye Keith S4,Tsuji Brian T35,Li Jian16,Nation Roger L1

Affiliation:

1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

2. Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

3. School of Pharmacy and Pharmaceutical Sciences, University at Buffalo State University of New York, Buffalo, NY, USA

4. Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA

5. Laboratory for Antimicrobial Pharmacodynamics, NYS Centre of Excellence in Bioinformatics & Life Sciences, Buffalo, NY, USA

6. Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia

Funder

NIH

National Institute of Allergy and Infectious Diseases

NHMRC

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

Reference36 articles.

1. Colistin and polymyxin B: peas in a pod, or chalk and cheese?;Nation;Clin Infect Dis,2014

2. Differences in potency and categorical agreement between colistin and polymyxin B when testing 15,377 clinical strains collected worldwide;Sader;Diagn Microbiol Infect Dis,2015

3. Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus;Nation;Lancet Infect Dis,2015

4. Pharmacokinetic/pharmacodynamic investigation of colistin against Pseudomonas aeruginosa using an in vitro model;Bergen;Antimicrob Agents Chemother,2010

5. New pharmacokinetic/pharmacodynamic studies of systemically administered colistin against Pseudomonas aeruginosa and Acinetobacter baumannii in mouse thigh and lung infection models: smaller response in lung infection;Cheah;J Antimicrob Chemother,2015

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