Impact of pegfilgrastim as primary prophylaxis for metastatic castration-resistant prostate cancer patients undergoing cabazitaxel treatment: an open-label study in Japan

Author:

Kosaka Takeo1,Uemura Hiroji2,Sumitomo Makoto3,Harada Kenichi4,Sugimoto Mikio5,Hayashi Narihiko6,Yoshimura Kazuhiro7,Fukasawa Satoshi8,Ecstein-Fraisse Evelyne9,Sunaga Yoshinori10,Oya Mototsugu1

Affiliation:

1. Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

2. Department of Urology/Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune, Minami-ku, Yokohama 232-0024, Japan

3. Department of Urology, Aichi Medical University Hospital, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan

4. Department of Urology, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan

5. Department of Urology, Kagawa University Hospital, 1750-1 Ikenobe, Miki Kita-gun, Kagawa 761-0793, Japan

6. Department of Urology, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan

7. Department of Urology, Kindai University Hospital, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan

8. Department of Urology/Prostate Cancer, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba 260-0801, Japan

9. Medical Evidence Generation, Sanofi, 54 rue La Boétie, Paris 75008, France

10. Biostatistics Programming, Oncology, Sanofi, 640 Memorial Drive, Cambridge MA 02142, USA

Abstract

Primary prophylaxis with granulocyte colony-stimulating factor (G-CSF) reduced incidence of febrile neutropenia in Japanese metastatic castration-resistant prostate cancer patients. Cabazitaxel+G-CSF therapy was a safe and effective treatment option.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology,General Medicine

Reference23 articles.

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2. In vitro activity of TXD258 in chemotherapeutic resistant tumor cell lines;Aller;Proc Am Assoc Cancer Res,2000

3. Preclinical evaluation of new taxoids;Bissery;Curr Pharm Des,2001

4. Cabazitaxel, a new taxane with favorable properties;Bouchet;Drugs Today,2010

5. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial;de Bono;Lancet,2010

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