Separation and Characterization of Novel Degradation and Process Related Impurities of Bedaquiline Bulk Drug

Author:

Vanavi Pragati J1,Rajput Sadhana J1ORCID

Affiliation:

1. Centre for Relevance and Excellence in NDDS, Faculty of Pharmacy, Pharmaceutical Quality Assurance Laboratory, The Maharaja Sayajirao University of Baroda, Gujarat 390002, India

Abstract

Abstract Bedaquiline (BDQ) is a new drug approved by United States Food and Drug Administration (USFDA) in 2012 for the treatment of drug-resistant tuberculosis, which has become a major threat globally. The manuscript presents the development of three liquid chromatography (LC) based analytical methods. The first is a stability indicating RP-HPLC (reverse phase-high performance liquid chromatography) method to analyze the BDQ in presence of its degradation products. Another UPLC/ESI–MS (ultra-performance liquid chromatography/electron spray ionization–mass spectrometry) method was developed for the identification of different degradation based and process related impurities and the third, preparative HPLC method was developed for the isolation of major degradation products. Eleven degradation products and one process related impurity were identified using UPLC/ESI–MS whereas preparative HPLC was used to isolate two degradation products and their chemical structure was elucidated using nuclear magnetic resonance, mass and infra-red spectral data.

Publisher

Oxford University Press (OUP)

Subject

General Medicine,Analytical Chemistry

Reference17 articles.

1. Development and validation of UV spectrophotometric methods for the estimation of bedaquiline in bulk and pharmaceutical formulations;Pooja;World Journal of Pharmaceutical Research,2018

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