Chromatographic Methods for the Analysis of the Antipsychotic Drug Clozapine and Its Major Metabolites: A Review-Reference-Cited by-同舟云学术

Chromatographic Methods for the Analysis of the Antipsychotic Drug Clozapine and Its Major Metabolites: A Review

Published:2024-04-04 Issue: Volume: Page:
ISSN:0021-9665
Container-title:Journal of Chromatographic Science
language:en
Short-container-title:

Author:

Hrichi Hajer¹²,Kouki Noura³⁴,Elkanzi Nadia Ali Ahmed¹²

Affiliation:

1. Chemistry Department , College of Science, , P.O. Box: 2014, Sakaka , Saudi Arabia

2. Jouf University , College of Science, , P.O. Box: 2014, Sakaka , Saudi Arabia

3. Department of Chemistry , College of Science, , Buraidah 51452 , Saudi Arabia

4. Qassim University , College of Science, , Buraidah 51452 , Saudi Arabia

Abstract

Abstract Clozapine (CLZ), a second-generation antipsychotic, can effectively reduce schizophrenia, bipolar disorder and major depression symptoms. This review provides an overview of all reported chromatographic methods (62 references) for the quantification of CLZ and its two main metabolites, norclozapine and clozapine N-oxide in pharmaceutical formulations, biological matrices and environmental samples.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/chromsci/advance-article-pdf/doi/10.1093/chromsci/bmae016/57156308/bmae016.pdf

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