Fingerprinting and Determination of Hepatotoxic Constituents in Polygoni Multiflori Radix Praeparata of Different Producing Places by HPLC

Author:

Zhou Gui1,Feng Yi-Ming1,Li Zhi-Cheng2,Tao Li-Yu3,Kong Wei-Song1,Xie Rui-Fang1,Zhou Xin1

Affiliation:

1. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, South Wanping Road, Xuhui District, Shanghai 200032, China

2. Pudong Hospital, Fudan University, Gongwei Road, Pudong New District, Shanghai 201300, China

3. Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Zhangheng Road, Pudong New District, Shanghai 201203, China

Abstract

Abstract Polygoni Multiflori Radix Praeparata (PMRP) is used as Chinese herbal medicine with long history. However, reports about PMRP hepatotoxicity have increased recently, and producing area might be one reason. This article aims to figure out the relationship between producing area and hepatotoxic ingredients in PMRP. HPLC fingerprint for PMRP was established and the contents of gallic acid, trans-stilbene glycoside (TSG), emodin-8-O-β-D-glucoside (EG), emodin and physcion were determined. Clustering heatmap was implemented by TCMNPAS software,and principal component analysis was implemented by SPSS and SIMCA-P software. Hepatotoxic constituents’ contents of PMRP from separate producing area were different. PMRP from Guangxi had the highest content of gallic acid, TSG, EG, emodin and physcion, followed by Hubei, Guangdong, Guizhou, Yunnan. PMRP from Henan had the lowest contents of hepatotoxic components. Hepatotoxic components’ contents of PMRP in southern were higher than central China. This study carried out a preliminary qualitative and quantitative investigation on the PMRP from different producing places, which provided a basis for safe medication of PMRP.

Funder

Key Specialty Program of Clinical Pharmacy

Science and Technology Commission of Shanghai Municipality

Publisher

Oxford University Press (OUP)

Subject

General Medicine,Analytical Chemistry

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