1. Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds , Leeds LS2 9JT , UK
2. Department of Clinical Immunology and Allergy, St James’s University Hospital , Leeds , UK
3. National Institute for Health Research-Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, Wellcome Trust Brenner Building, St James’s University Hospital , Leeds , UK