Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart-Reference-Cited by-同舟云学术

Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

Published:2020-07-08 Issue:11 Volume:116 Page:1805-1819
ISSN:0008-6363
Container-title:Cardiovascular Research
language:en
Short-container-title:

Author:

Bär Christian¹²^ORCID,Chatterjee Shambhabi¹²^ORCID,Falcão Pires Inês³,Rodrigues Patrícia³^ORCID,Sluijter Joost P G⁴^ORCID,Boon Reinier A⁵⁶⁷^ORCID,Nevado Rosa M⁸⁹^ORCID,Andrés Vicente⁸⁹^ORCID,Sansonetti Marida¹²¹⁰¹¹,de Windt Leon¹⁰¹¹,Ciccarelli Michele¹²^ORCID,Hamdani Nazha¹³¹⁴^ORCID,Heymans Stephane¹⁵¹⁶,Figuinha Videira Raquel³¹⁰¹¹^ORCID,Tocchetti Carlo G¹⁷^ORCID,Giacca Mauro¹⁸¹⁹²⁰^ORCID,Zacchigna Serena¹⁸²⁰^ORCID,Engelhardt Stefan²¹²²^ORCID,Dimmeler Stefanie²³²⁴²⁵^ORCID,Madonna Rosalinda²⁶²⁷^ORCID,Thum Thomas¹²^ORCID

Affiliation:

1. Institute for Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany

2. REBIRTH Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany

3. Cardiovascular Research and Development Center, Faculty of Medicine, University of Porto, Porto, Portugal

4. Experimental Cardiology Laboratory, UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands

5. Department of Physiology, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands

6. Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany

7. Partner site Rhein/Main, German Center for Cardiovascular Research (DZHK), Frankfurt am Main, Germany

8. Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

9. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain

10. Department of Molecular Genetics, Faculty of Science and Engineering, Maastricht University, Maastricht, The Netherlands

11. Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands

12. Department of Medicine, Surgery and Dentistry, University of Salerno, Italy

13. Department of Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany

14. Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany

15. Department of Cardiology, Maastricht University Medical Centre, University Hospital Maastricht, The Netherlands

16. Center for Heart Failure Research, Cardiovascular Research Institute Maastricht (CARIM), University Hospital Maastricht, The Netherlands

17. Department of Translational Medical Sciences and Interdepartmental Center of Clinical and Translational Research (CIRCET), Federico II University, Naples, Italy

18. International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy

19. School of Cardiovascular Medicine & Sciences, King’s College London, London, UK

20. Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy

21. Institute of Pharmacology and Toxicology, Technische Universität München, Biedersteiner Str. 29, Munich 80802, Germany

22. DZHK (German Center for Cardiovascular Research), Partner site Munich Heart Alliance, Biedersteiner Str. 29, Munich 80802, Germany

23. Institute for Cardiovascular Regeneration, Goethe University, Germany

24. German Center for Cardiovascular Research (DZHK), Frankfurt, Germany

25. Cardio-Pulmonary Institute (CPI), Frankfurt, Germany

26. Institute of Cardiology, University of Pisa, Pisa, Italy

27. Department of Internal Medicine, University of Texas Medical School, Houston, TX, USA

Abstract

Abstract Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.

Funder

Deutsche Forschungsgemeinschaft

DFG

ERANet CVD

Federico II University

Ricerca di Ateneo

Fundo Europeu de Desenvolvimento Regional

Compete 2020—Programa Operacional Competitividade E Internacionalização

NETDIAMOND

European Structural and Investment Funds

FCT

Ministero dell’Istruzione