Sensitive and specific assay for the serological diagnosis of anti-p200 pemphigoid based on the recombinant laminin β4 subunit-Reference-Cited by-同舟云学术

Sensitive and specific assay for the serological diagnosis of anti-p200 pemphigoid based on the recombinant laminin β4 subunit

Published:2024-03-28 Issue:1 Volume:191 Page:140-141
ISSN:0007-0963
Container-title:British Journal of Dermatology
language:en
Short-container-title:

Author:

Goletz Stephanie¹^ORCID,Probst Christian²^ORCID,Komorowski Lars²^ORCID,Radzimski Christiane²^ORCID,Mindorf Swantje²^ORCID,Holtsche Maike M¹³^ORCID,Pigors Manuela¹^ORCID,van Beek Nina¹³^ORCID,Zillikens Detlef³,Schlumberger Wolfgang²,Schmidt Enno¹³^ORCID

Affiliation:

1. Lübeck Institute of Experimental Dermatology

2. Institute of Experimental Immunology, EUROIMMUN AG , Lübeck , Germany

3. Department of Dermatology, University of Lübeck

Abstract

Anti-p200 pemphigoid is an autoimmune blistering disease that often resembles other pemphigoid disorders. We developed a test for the detection of autoantibodies against laminin β4, an autoantigen in anti-p200 pemphigoid, to facilitate its diagnosis. The test demonstrated excellent sensitivity and specificity, making it a valuable tool for diagnosing this disease and distinguishing it from similar skin disorders.

Funder

Precision Medicine in Chronic Inflammation

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljae136/57700609/ljae136.pdf

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