Genomic profiling of a skin adnexal carcinomas cohort using a comprehensive high-throughput sequencing approach

Author:

Louveau Baptiste12,Nakouri Ines23,Jouenne Fanélie12,Baroudjian Barouyr3,Sadoux Aurélie1,Da Meda Laetitia3,Osio Amélie456,Reinhart Fanny4,Robert Julien7,Herms Florian3,Cribier Bernard68,Mortier Laurent69,Jouary Thomas610,Basset Seguin Nicole23,Lebbé Céleste23,Mourah Samia12,Battistella Maxime246ORCID

Affiliation:

1. Department of Pharmacology and Tumor Genomics, DMU BioGeM, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris , Paris , France

2. Université Paris Cité, INSERM UMR-S 976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI) , Paris , France

3. Department of Dermatology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris , Paris , France

4. Department of Pathology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris , Paris , France

5. CND-Paris la Roquette , Ivry , France

6. French Network of Rare Skin Cancers, CARADERM , France

7. DMU BioGeM, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris , Paris , France

8. Dermatology and Dermatopathology, Faculty of Medicine, University Hospital, University of Strasbourg , Strasbourg , France

9. Department of Dermatology, Claude Huriez Hospital and University of Lille , Lille , France

10. Department of Dermatology, Hospital Center of Pau , Pau , France

Abstract

We conducted a comprehensive molecular characterization of a cohort of 77 patients with skin adnexal carcinomas and compared our findings with those of other skin carcinomas. We highlighted genomic profiles bringing insights regarding classification, tumorigenesis processes and therapeutic options.

Publisher

Oxford University Press (OUP)

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