Granuloma annulare and the risk of autoimmune conditions: a multicentre retrospective cohort analysis

Author:

Garate David1ORCID,Thang Christopher J12ORCID,Schmidt Madelyn1ORCID,Ravanassa Shayan1ORCID,Jimenez Antonio R3ORCID,Ross Lindy S3ORCID,Golovko George4ORCID,Barbieri John S5ORCID,Wilkerson Michael G3ORCID

Affiliation:

1. John Sealy School of Medicine, University of Texas Medical Branch , Galveston, TX , USA

2. Department of Dermatology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA

3. Department of Dermatology, University of Texas Medical Branch , Galveston, TX , USA

4. Department of Pharmacology and Toxicology, University of Texas Medical Branch,    Galveston, TX , USA

5. Department of Dermatology, Brigham and Women’s Hospital , Boston, MA , USA

Abstract

Prior studies and case reports have postulated potential associations between granuloma annulare (GA) and various autoimmune conditions, but these relationships remain unclear. Using the TriNetX Research Network, we found that GA was significantly associated with an increased risk of systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroiditis and type 1 diabetes mellitus, along with point estimates suggesting an increased risk of systemic sclerosis and uveitis. Overall, our study uses epidemiological data to provide valuable evidence supporting an increased risk of autoimmune disorders in people with GA.

Publisher

Oxford University Press (OUP)

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