Dupilumab in chronic actinic dermatitis: a retrospective case series

Author:

O’Reilly Marese1,Paolino Alexandra2,Pathmarajah Pirunthan2,Ferguson John2,Smith Catherine H2,Sarkany Robert2,Dawe Robert S12,Salam Amr2,Pink Andrew E2,Fassihi Hiva2,Ibbotson Sally1

Affiliation:

1. Photobiology Unit, Ninewells Hospital , Dundee , UK

2. St John’s Institute of Dermatology, Guy’s and St Thomas’ NHS Foundation Trust , London , UK

Abstract

We report a retrospective case series from two UK photobiology units of 12 patients with concomitant atopic dermatitis (AD) and chronic actinic dermatitis (CAD) treated with dupilumab as a systemic monotherapy. While dupilumab is an effective therapy for moderate-to-severe AD, our results suggest that it may be less effective for the photosensitivity of CAD. In 11 of 12 patients with CAD, dupilumab was associated with improvement in dermatitis, but only half the patients noted improvement in photosensitivity.

Publisher

Oxford University Press (OUP)

Reference8 articles.

1. The effectiveness and safety of ­dupilumab for the treatment of recalcitrant chronic actinic dermatitis: a case series;Chen;Clin Cosmet Investig Dermatol,2023

2. Dupilumab for the treatment of chronic actinic dermatitis;Patel;Photoderm Photoimmunol Photomed,2020

3. Successful treatment of chronic actinic dermatitis with dupilumab: a case report and review of the literature;Chen;Clin Cosmet Investig Dermatol,2021

4. A case report of therapeutically challenging chronic actinic dermatitis;Verma;SAGE Open Med Case Rep,2019

5. Dupilumab for the treatment of severe photodermatitis;Smith;JAAD Case Rep,2019

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