Candidaemia and <i>Candida</i> colonization in patients with epidermal necrolysis: a retrospective case series-Reference-Cited by-同舟云学术

Candidaemia and Candida colonization in patients with epidermal necrolysis: a retrospective case series

Published:2024-06-14 Issue: Volume: Page:
ISSN:0007-0963
Container-title:British Journal of Dermatology
language:en
Short-container-title:

Author:

Chantelot Louise¹,Gaillet Antoine¹²,Botterel Françoise³⁴,Ingen-Housz-Oro Saskia⁵⁶⁷⁸^ORCID,de Prost Nicolas¹²⁶⁸⁹^ORCID

Affiliation:

1. AP-HP, Hôpitaux Universitaires Henri-Mondor, Service de Médecine Intensive Réanimation , F-94010, Créteil , France

2. Groupe de Recherche Clinique CARMAS, Université Paris-Est-Créteil (UPEC) , Créteil , France

3. AP-HP, Hôpitaux Universitaires Henri-Mondor, Unité de Parasitologie-Mycologie , F-94010, Créteil , France

4. Dynamyc, UPEC, EnvA, USC ANSES

5. AP-HP, Hôpitaux Universitaires Henri-Mondor Mondor, Service de Dermatologie, F-94010, Créteil, France Université Paris-Est-Créteil (UPEC) , Créteil , France

6. Université Paris-Est-Créteil (UPEC) , Créteil , France

7. Université Paris-Est-Créteil EpiDermE , Créteil , France

8. Center for Toxic Bullous Diseases and Severe Drug Reactions TOXIBUL, AP-HP, Hôpitaux Universitaires Henri-Mondor , Créteil , France

9. IMRB INSERM U955, Team ‘Viruses, Hepatology, Cancer’ , Créteil , France

Abstract

Sepsis is a leading cause of death in patients with epidermal necrolysis (EN). However, fungal infections have rarely been reported. From a monocentric retrospective study conducted between 2000 and 2023 in the medical intensive care unit of the reference centre for severe drug reactions in France, we report on the epidemiology of candidaemia and Candida sp. colonization in patients with EN. Of 155 patients with EN who were admitted to the ICU, 36 had a positive Candida sp. skin culture without candidaemia, 12 developed candidaemia and 107 had a negative skin culture and no candidaemia. Skin cultures showed a good sensitivity [89%; 95% CI (52–100%)] and excellent negative predictive values [99%; 95% CI (94–100%)] for candidaemia.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljae252/58600152/ljae252.pdf

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