Single-cell transcriptomic analysis identifies infiltrating plasmacytoid dendritic cells in psoriasis epidermis-Reference-Cited by-同舟云学术

Single-cell transcriptomic analysis identifies infiltrating plasmacytoid dendritic cells in psoriasis epidermis

Published:2024-05-22 Issue: Volume: Page:
ISSN:0007-0963
Container-title:British Journal of Dermatology
language:en
Short-container-title:

Author:

Luo Longlong¹²^ORCID,Cheng Huaitao³^ORCID,Liu Zhuang⁴^ORCID,Olszewski Pawel¹^ORCID,Pasquali Lorenzo⁴^ORCID,Xu Ning⁴^ORCID,Enge Martin³^ORCID,Pivarcsi Andor¹^ORCID,Sonkoly Enikö¹²^ORCID

Affiliation:

1. Department of Medical Biochemistry and Microbiology (IMBIM) , Uppsala University, Uppsala , Sweden

2. Dermatology and Venereology, Department of Medical Sciences, Uppsala University , Uppsala , Sweden

3. Department of Oncology and Pathology, Karolinska Institutet , Stockholm , Sweden

4. Dermatology and Venereology Division, Department of Medicine Solna, Karolinska Institutet , Stockholm , Sweden

Abstract

Our study unveils the cellular and molecular dynamics in psoriasis epidermis, revealing diverse cell states and their interactions driving inflammation and altered developmental trajectories. Importantly, a previously overlooked plasmacytoid dendritic cell cluster with inflammatory properties was identified in the epidermis of chronic psoriasis lesions, suggesting a potential role for these cells in chronic psoriasis.

Funder

Swedish Medical Research Council

National Psoriasis Foundation

China Scholarship Council

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljae210/58378800/ljae210.pdf

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