SUCLG2 identified as both a determinator of CSF Aβ1–42 levels and an attenuator of cognitive decline in Alzheimer's disease

Author:

Ramirez Alfredo12,van der Flier Wiesje M.34,Herold Christine5,Ramonet David6,Heilmann Stefanie27,Lewczuk Piotr8,Popp Julius1,Lacour André5,Drichel Dmitriy5,Louwersheimer Eva34,Kummer Markus P.65,Cruchaga Carlos910,Hoffmann Per2711,Teunissen Charlotte34,Holstege Henne34,Kornhuber Johannes8,Peters Oliver12,Naj Adam C.13,Chouraki Vincent1415,Bellenguez Céline161718,Gerrish Amy19,Heun Reiner1,Frölich Lutz20,Hüll Michael21,Buscemi Lara22,Herms Stefan2711,Kölsch Heike1,Scheltens Philip34,Breteler Monique M.5,Rüther Eckart23,Wiltfang Jens23,Goate Alison924,Jessen Frank15,Maier Wolfgang15,Heneka Michael T.65,Becker Tim255,Nöthen Markus M.27, ,

Affiliation:

1. Department of Psychiatry and Psychotherapy,

2. Institute of Human Genetics,

3. Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HZ, Amsterdam, The Netherlands,

4. Department of Epidemiology & Biostatistics, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands,

5. German Center for Neurodegenerative Diseases (DZNE), 53175, Bonn, Germany,

6. Clinical Neuroscience Unit, Department of Neurology,

7. Department of Genomics, Life & Brain Center,

8. Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, 91054, Erlangen, Germany,

9. Department of Psychiatry,

10. Hope Center for Neurological Disorders, School of Medicine,

11. Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, CH-4058, Basel, Switzerland,

12. Department of Psychiatry, Charité, 14050, Berlin, Germany,

13. Center for Clinical Epidemiology & Biostatistics, University of Pennsylvania, PA 19104, Philadelphia, USA,

14. Department of Neurology, Boston University School of Medicine, MA 02118, Boston, USA,

15. The Framingham Heart Study, MA 01702, Framingham, USA,

16. Inserm, U744, Lille59000, France,

17. Université Lille 2, Lille59000, France,

18. Institut Pasteur de Lille, Lille59000, France,

19. Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK,

20. Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159, Mannheim, Germany,

21. Centre for Geriatric Medicine and Section of Gerontopsychiatry and Neuropsychology, Medical School, University of Freiburg, 79106, Freiburg, Germany,

22. Department of Fundamental Neurosciences, UNIL, 1005 Lausanne, Switzerland and

23. Department of Psychiatry and Psychotherapy, University of Göttingen, 37075Göttingen, Germany

24. Department of Genetics, Washington University, St. Louis, MO 63110, USA,

25. Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, 53127, Bonn, Germany,

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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