A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium

Author:

,Jia Yu-Juan12,Wang Jun1,Ren Jun-Rong1,Chan Piu3,Chen Shengdi4,Chen Xiao-Chun5,Chhetri Jagadish K3,Guo Junhong2,Guo Qihao6,Jin Lingjing7,Liu Qiang8,Liu Qiang9,Ma Wenlin10,Mao Zhiyong11,Song Moshi12,Song Weihong13,Tang Yi14ORCID,Wang Difei15,Wang Peijun16,Xiong Lize17,Ye Keqiang18,Zhang Junjian19,Zhang Weiqi20,Zhang Xiaoqing21,Zhang Yunwu22,Zhang Zhanjun23ORCID,Zhang Zhuohua24,Zheng Jialin25,Liu Guang-Hui261227,Eve Sun Yi28,Wang Yan-Jiang2930,Pei Gang31

Affiliation:

1. Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University , Chongqing 400042 , China

2. Department of Neurology, First Affiliated Hospital, Shanxi Medical University , Taiyuan 030001 , China

3. National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University , Beijing 100053 , China

4. Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China

5. Department of Neurology, Union Hospital of Fujian Medical University , Fuzhou 350001 , China

6. Department of Gerontology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200233 , China

7. Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons’ Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University, School of Medicine , Shanghai 200092 , China

8. Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230026 , China

9. Department of Neurology, Institute of Neuroimmunology, Tianjin Medical University General Hospital , Tianjin 300052 , China

10. Department of Cardiology, Shanghai Tongji Hospital, Tongji University School of Medicine , Shanghai 200092 , China

11. Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University , Shanghai 200092 , China

12. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 , China

13. Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Zhejiang Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Oujiang Laboratory , Wenzhou, Zhejiang 325035 , China

14. Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders , Beijing 100053 , China

15. Department of Gerontology, Shengjing Hospital of China Medical University, Shenyang 110000 , China

16. Department of Radiology, Tongji Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University , Shanghai 200092 , China

17. Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, Tongji University , Shanghai 200434 , China

18. Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Science , Shenzhen 518055 , China

19. Department of Neurology, Zhongnan Hospital of Wuhan University , Wuhan 430071 , China

20. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation , Beijing 100101 , China

21. Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai 200120 , China

22. Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University , Xiamen 361102 , China

23. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University , Beijing 100875 , China

24. Hunan Key Laboratory of Molecular Precision Medicine, Department of Critical Care Medicine, Xiangya Hospital, Central South University , Changsha 410008 , China

25. Center for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital affiliated to Tongji University School of Medicine , Shanghai 200072 , China

26. University of Chinese Academy of Sciences , Beijing 100049 , China

27. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing 100101 , China

28. Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine , Shanghai 200065 , China

29. Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University , Chongqing 400042 , China

30. Key Laboratory of Ageing and Brain Disease , Chongqing 400042 , China

31. Collaborative Innovation Center for Brain Science, School of Life Science and Technology, Tongji University , Shanghai 200092 , China

Abstract

Abstract China and the world are facing severe population aging and an increasing burden of age-related diseases. Aging of the brain causes major age-related brain diseases, such as neurodegenerative diseases and stroke. Identifying biomarkers for the effective assessment of brain aging and establishing a brain aging assessment system could facilitate the development of brain aging intervention strategies and the effective prevention and treatment of aging-related brain diseases. Thus, experts from the Aging Biomarker Consortium (ABC) have combined the latest research results and practical experience to recommend brain aging biomarkers and form an expert consensus, aiming to provide a basis for assessing the degree of brain aging and conducting brain-aging-related research with the ultimate goal of improving the brain health of elderly individuals in both China and the world.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Reference85 articles.

1. The landscape of aging;Cai;Sci China Life Sci,2022

2. Biomarkers of aging;Aging Biomarker;Sci China Life Sci,2023

3. Methodology manual for European Association for Cardio-Thoracic Surgery (EACTS) clinical guidelines;Sousa-Uva;Eur J Cardiothorac Surg,2015

4. Trajectories of age-related cognitive decline and potential associated factors of cognitive function in senior citizens of Beijing;Li;Curr Alzheimer Res,2014

5. Episodic memory in normal aging and Alzheimer disease: insights from imaging and behavioral studies;Tromp;Ageing Res Rev,2015

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