Peripheral immune landscape and natural killer-like B cells in human Vogt-Koyanagi-Harada disease

Author:

Li He1,Zhu Lei1,Liu Xiuxing1,Xie Lihui1,Wang Rong1,Li Zhaohuai1,Huang Zhaohao1,Yang Shizhao1,Chen Binyao1,Ye Jinguo1,Zheng Yingfeng1,Su Wenru1

Affiliation:

1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science , Guangzhou 510060 , China

Abstract

AbstractVogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder threatening the eyesight. The pathogenic mechanisms and biomarkers reflecting disease severity and predicting treatment response require further exploration. Here, we performed a single-cell analysis of peripheral blood mononuclear cells (PBMC) obtained from eight patients with VKH disease and eight healthy controls to comprehensively delineate the changes in VKH disease. We showed a mixture of inflammation, effector, and exhausted states for PBMCs in VKH disease. Notably, our study implicated a newly identified B cell subset, natural killer-like B cells (K-BC) characterized by expressing CD19 and CD56, was correlated with VKH disease. K-BCs expanded in VKH disease, fell back after effective treatment, and promoted the differentiation of pathogenic T cells. Overall, we mapped the peripheral immune cell atlas in VKH disease and indicated the pathogenic role and potential value in predicting treatment response of K-BCs.

Publisher

Oxford University Press (OUP)

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