A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium

Author:

,Zhang Le12ORCID,Guo Jun3,Liu Yuehong4,Sun Shimin5,Liu Baohua6ORCID,Yang Qi4ORCID,Tao Jun7,Tian Xiao-Li8,Pu Jun9ORCID,Hong Huashan10,Wang Miao1112,Chen Hou-Zao1314ORCID,Ren Jie15,Wang Xiaoming16,Liang Zhen17,Wang Yuan18,Huang Kai19202122,Zhang Weiqi15,Qu Jing23,Ju Zhenyu24,Liu Guang-Hui252627ORCID,Pei Gang28,Li Jian3ORCID,Zhang Cuntai12

Affiliation:

1. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030 , China

2. Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030 , China

3. The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission , Beijing 100730 , China

4. Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University , Beijing 100020 , China

5. Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital , Jena 07743 , Germany

6. School of Basic Medical Sciences, Shenzhen University Medical School , Shenzhen 518055 , China

7. Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun-Yat-sen University , Guangzhou 510080 , China

8. Aging and Vascular Diseases, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging , Nanchang 330031 , China

9. Division of Cardiology, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute , Shanghai 200127 , China

10. Department of Geriatrics, Fujian Key Laboratory of Vascular Aging, Fujian Medical University Union Hospital , Fuzhou 350001 , China

11. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100037 , China

12. Clinical Pharmacology Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100037 , China

13. Department of Biochemistry & Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100005 , China

14. Medical Epigenetics Research Center, Chinese Academy of Medical Sciences , Beijing 100005 , China

15. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation , Beijing 100101 , China

16. Department of Geriatrics, Xijing Hospital, Air Force Medical University , Xi’an 710032 , China

17. Shenzhen People’s Hospital , Shenzhen 518020 , China

18. Beijing Anzhen Hospital, Capital Medical University , Beijing 100029 , China

19. Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 , China

20. Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology , Wuhan 430022 , China

21. Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong University of Science and Technology , Wuhan 430022 , China

22. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 , China

23. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 , China

24. Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University , Guangzhou 510632 , China

25. University of Chinese Academy of Sciences , Beijing 100049 , China

26. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 , China

27. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing 100101 , China

28. Collaborative Innovation Center for Brain Science, School of Life Science and Technology , Tongji University, Shanghai 200092 , China

Abstract

Abstract Aging of the vasculature, which is integral to the functioning of literally all human organs, serves as a fundamental physiological basis for age-related alterations as well as a shared etiological mechanism for various chronic diseases prevalent in the elderly population. China, home to the world’s largest aging population, faces an escalating challenge in addressing the prevention and management of these age-related conditions. To meet this challenge, the Aging Biomarker Consortium of China has developed an expert consensus on biomarkers of vascular aging (VA) by synthesizing literature and insights from scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with VA and presents a systemic framework to classify them into three dimensions: functional, structural, and humoral. Within each dimension, the expert panel recommends the most clinically relevant VA biomarkers. For the functional domain, biomarkers reflecting vascular stiffness and endothelial function are highlighted. The structural dimension encompasses metrics for vascular structure, microvascular structure, and distribution. Additionally, proinflammatory factors are emphasized as biomarkers with the humoral dimension. The aim of this expert consensus is to establish a foundation for assessing the extent of VA and conducting research related to VA, with the ultimate goal of improving the vascular health of the elderly in China and globally.

Funder

National Key Research and Development Program of China

Publisher

Oxford University Press (OUP)

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