Candida auris from the Egyptian cobra: Role of snakes as potential reservoirs

Author:

Cafarchia Claudia1ORCID,Mendoza-Roldan Jairo A1,Rhimi Wafa1,C I Ugochukwu Iniobong12,Miglianti Mara1,Beugnet Frederic3,Giuffrè Letterio4,Romeo Orazio4ORCID,Otranto Domenico15

Affiliation:

1. Department of Veterinary Medicine, University of Bari Aldo Moro , Bari , Italy , 70010

2. Department of Veterinary Pathology and Microbiology, University of Nigeria , Nsukka , Nigeria , 410001

3. Boehringer-Ingelheim Animal Health , Lyon , France , 69007

4. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina , Messina , Italy , 98122

5. Department of Veterinary Clinical Sciences, City University of Hong Kong , 518057

Abstract

Abstract Candida auris represents one of the most urgent threats to public health, although its ecology remains largely unknown. Because amphibians and reptiles may present favorable conditions for C. auris colonization, cloacal and blood samples (n = 68), from several snake species, were cultured and molecularly screened for C. auris using molecular amplification of glycosylphosphatidylinositol protein-encoding genes and ribosomal internal transcribed spacer sequencing. Candida auris was isolated from the cloacal swab of one Egyptian cobra (Naja haje legionis) and molecularly identified in its cloaca and blood. The isolation of C. auris from wild animals is herein reported for the first time, thus suggesting the role that these animals could play as reservoirs of this emerging pathogen. The occurrence of C. auris in blood requires further investigation, although the presence of cationic antimicrobial peptides in the plasma of reptiles could play a role in reducing the vitality of the fungus.

Publisher

Oxford University Press (OUP)

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