Conditional immortalization of human cardiomyocytes for translationalin vitromodelling of cardiovascular disease
Author:
Affiliation:
1. Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center , Leiden , the Netherlands
2. Department of Cardiothoracic Surgery, Leiden University Medical Center , Leiden , the Netherlands
Funder
LUMC Executive Board
Leiden Regenerative Medicine Platform Holding
More Knowledge with Fewer Animals
Netherlands Organisation for Health Research and Development
Dutch Society for the Replacement of Animal Testing
Publisher
Oxford University Press (OUP)
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology
Link
https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvac078/43934710/cvac078.pdf
Reference10 articles.
1. The future of atrial fibrillation management: integrated care and stratified therapy;Kirchhof;Lancet,2017
2. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC working group on cellular biology of the heart;van der Velden;Cardiovasc Res,2022
3. Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation;Harlaar;Nat Biomed Eng,2022
4. Modeling atrial fibrillation using human embryonic stem cell-derived atrial tissue;Laksman;Sci Rep,2017
5. Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes;Goldfracht;Nat Commun,2020
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